1. Bioactive plant secondary metabolites

The search for new bioactive secondary metabolites is one of the traditional pillars of Pharmaceutical Biology. In past research projects, we have isolated and characterised dozens of previously unknown compounds from various compound classes such as iridoids, flavonoids, phenolic acids, sesquiterpenes, diterpenes, and polyacetylenes. New bioactive metabolites from natural sources continue to be one of the main sources of novel lead compounds in the early stages of drug development. Our research is mainly focused on plant secondary metabolites from European plant species. Contrary to general perception, even from European plant taxa so far only a minority has been intensively studied phytochemically. Thus, the more biodiverse regions of Europe, such as the Alps and the Mediterranean area, continue to yield novel exciting bioactive substances.

 

Review

Ethnobotany, phytochemistry, and bioactivity of the genus Turnera (Passifloraceae) with a focus on damiana – Turnera diffusa. J. Ethnopharm. 152, 424-443. doi:10.1016/j.jep.2014.01.019

 

Original publications

Granica, S., Piwowarski, J.P., Randazzo, A., Schneider, P., Żyżyńska-Granica, B., Zidorn, C., 2015. Novel stilbenoids, including cannabispiradienone glycosides, from Tragopogon tommasinii (Asteraceae, Cichorieae) and their potential anti-inflammatory activity. Phytochemistry 117, 254-266. doi:10.1016/j.phytochem.2015.06.018

Cicek, S.S., Khom, S., Taferner, B., Hering, S., Stuppner, H., 2010. Bioactivity-Guided Isolation of GABA(A) Receptor Modulating Constituents from the Rhizomes of Actaea racemosa. J. Nat. Prod. 73, 2024-2028. doi:10.1021/np100479w

Zidorn, C., Petersen, B. O., Sareedenchai, V., Ellmerer, E. P., Duus, J.Ø., 2010. Tragoponol, a dimeric dihydroisocoumarin from Tragopogon porrifolius L. Tetrahedron Lett. 51, 1390-1393. doi:10.1016/j.tetlet.2010.01.016

Zidorn, C., Petersen, B.O., Udovičić, V., Larsen, T.O., Duus, J.Ø., Rollinger, J.M., Ongania, K.-H., Ellmerer, E.P., Stuppner, H., 2005. Podospermic acid, 1,3,5-tri-O-(7,8-dihydrocaffeoyl)quinic acid from Podospermum laciniatum (Asteraceae). Tetrahedron Lett. 46, 1291-1294. doi:10.1016/j.tetlet.2004.12.118

Zidorn, C., Ellmerer, E.P., Sturm, S., Stuppner, H., 2003. Tyrolobibenzyls E and F from Scorzonera humilis and distribution of caffeic acids, lignans and tyrolobibenzyls in European taxa of the subtribe Scorzonerinae (Lactuceae, Asteraceae). Phytochemistry 63, 61-67. doi:10.1016/S0031-9422(02)00714-8

Perry, N. B., Span, E. M., Zidorn, C., 2001. Aciphyllal - a C34-polyacetylene from Aciphylla scott-thomsonii (Apiaceae). Tetrahedron Lett. 42, 4325-4328. doi:10.1016/S0040-4039(01)00720-1